Snapshot A 65-year-old man presents to his primary care physician with generalized fatigue and lower back bone pain. He reports an unexpected 20-pound weight loss over the course of 3 months. Physical examination is notable for conjunctival pallor and tenderness upon palpation of the lower spine. Laboratory studies are notable for a normocytic, normochromic anemia, hypercalcemia, and renal insufficiency. Urine electrophoresis is notable for Bence Jones proteins. Introduction Overview login to view 4 more bullets Epidemiology Demographics login to view 2 more bullets Risk factors login to view 1 more bullet ETIOLOGY Pathophysiology login to view 1 more bullet Associated conditions login to view 4 more bullets Presentation Symptoms login to view 16 more bullets Imaging Radiography login to view 5 more bullets Whole body low-dose CT scan login to view 2 more bullets MRI whole body (or spine and pelvis) login to view 4 more bullets PET scan login to view 3 more bullets Studies Serum labs login to view 17 more bullets Invasive studies login to view 5 more bullets Imaging login to view 1 more bullet Differential MGUS login to view 4 more bullets Waldenstrom macroglobulinemia login to view 3 more bullets Treatment Medical login to view 4 more bullets Complications May lead to login to view 6 more bullets