Snapshot A 72-year-old man presents to his primary care physician with fatigue. His symptoms are associated with fevers, chills, and nightsweats. He lost 25 pounds over the course of 3 months unintentionally. Laboratory studies are remarkable for an anemia. Other serum studies demonstrates a monoclonal IgM gammopathy. Bone marrow biopsy demonstrates 12% bone marrow infiltration of small lymphocytes with plasma cell differentiation. Introduction Overview login to view 2 more bullets ETIOLOGY Pathophysiology login to view 15 more bullets Genetics login to view 4 more bullets Associated conditions login to view 1 more bullet Epidemiology Demographics login to view 2 more bullets Presentation Symptoms login to view 6 more bullets Studies Serum labs login to view 2 more bullets Invastive studies login to view 3 more bullets Histology login to view 1 more bullet Differential Multiple myeloma login to view 7 more bullets Monoclonal gammopathy of undetermined significance (MGUS) login to view 4 more bullets Treatment There is no standard therapy Medical login to view 3 more bullets Complications Hyperviscosity Peripheral neurology Cryoglobulinemia Amyloid amyloidosis Prognosis Median survival is ~10 years from time of diagnosis