Snapshot A 12-year-old boy presents to the pediatric emergency department with pain in his right lower extremity. He was recently playing in soccer, but he denies any trauma to the leg. Physical examination is notable for mild swelling in the right mid-tibia and tenderness to palpation. A radiograph of the leg demonstrate periosteal elevation and "onion skinning" concerning for malignancy. Introduction Overview login to view 3 more bullets Epidemiology Incidence login to view 2 more bullets ETIOLOGY Pathophysiology login to view 1 more bullet Genetics login to view 2 more bullets Symptoms Symptom login to view 5 more bullets Physical exam login to view 1 more bullet Imaging Radiography login to view 8 more bullets MRI login to view 3 more bullets Radionuclide bone scan login to view 2 more bullets Studies Invasive studies login to view 11 more bullets Differential Osteosarcoma login to view 4 more bullets Treatment Medical login to view 6 more bullets Operative login to view 3 more bullets Complications Metastasis login to view 3 more bullets