Review Question - QID 109584

A 78-year-old man presents to his primary care physician for persistent back pain. The patient states that he has had intermittent back pain; however, this past weekend he was helping his son move heavy furniture. Since the move, his symptoms have been more severe. The patient states that the pain is constant and occurs throughout the day. On review of systems, the patient endorses a recent 15-pound weight loss and constipation. His temperature is 99.5°F (37.5°C), blood pressure is 137/79 mmHg, pulse is 90/min, respirations are 15/min, and oxygen saturation is 98% on room air. A cardiovascular exam is notable for a murmur at the right sternal border that radiates to the carotids. A pulmonary exam reveals mild bibasilar crackles. A musculoskeletal exam is notable for mild midline tenderness of the lower thoracic spine and the upper segment of the lumbar spine. No bruising or signs of external trauma are observable on the back. Symptoms are not exacerbated when the patient is lying down and his straight leg is lifted. Strength is 5/5 in the lower and upper extremities. The patient's sensation is intact bilaterally in his lower and upper extremities. Laboratory values are ordered and return as seen below.

Hemoglobin: 11 g/dL
Hematocrit: 34%
Leukocyte count: 10,500/mm^3 with normal differential
Platelet count: 288,000/mm^3

Serum:
Na+: 139 mEq/L
Cl-: 100 mEq/L
K+: 4.3 mEq/L
HCO3-: 25 mEq/L
BUN: 20 mg/dL
Glucose: 99 mg/dL
Creatinine: 1.6 mg/dL
Ca2+: 11.8 mg/dL
AST: 12 U/L
ALT: 12 U/L

Which of the following is the most likely diagnosis?