Snapshot A 63-year-old man is brought to the physician's office by his son due to progressively worsening headache and weakness. His headache began approximately 3 months prior to presentation and is described as diffuse but worse on the right-side of the head. The headache worsens with coughing and lifting heavy objects and is associated with nausea, multiple episodes of vomiting, and left-sided weakness. He previously worked for the synthetic rubber industry for over 30 years. Physical examination is significant for 3/5 strength in the left upper and lower extremity. Magnetic resonance imaging (MRI) of the head is shown. Introduction Clinical definition login to view 1 more bullet Epidemiology Incidence login to view 2 more bullets Demographics login to view 1 more bullet Risk factors login to view 10 more bullets ETIOLOGY Pathogenesis login to view 2 more bullets Presentation Symptoms login to view 8 more bullets Physical exam login to view 1 more bullet Imaging MRI login to view 7 more bullets Studies Histology login to view 5 more bullets Differential Anaplastic astrocytoma Metastatic brain cancer Demyelination Treatment Medical login to view 3 more bullets Surgical login to view 4 more bullets Complications Survivors glioblastoma can result in login to view 4 more bullets Prognosis This is typically a poor prognosis login to view 1 more bullet