Snapshot A 65-year-old man with mycosis fungoides presents with increased fatigue, low-grade fevers, and night sweats. Given his history, he is scared that "something is going on." His primary care physician does a thorough physical exam and finds several small, rubbery, mobile supraclavicular lymph nodes. They are nontender. A lymph node biopsy shows pathology of Reed-Sternberg cells. Introduction B-cell malignancy originating in lymphatic system Commonly early stage when diagnosed login to view 1 more bullet Types of Hodgkin lymphoma login to view 9 more bullets Epidemiology Incidence login to view 3 more bullets Demographics login to view 2 more bullets Risk factors login to view 4 more bullets ETIOLOGY Pathogenesis login to view 4 more bullets Presentation Symptoms login to view 7 more bullets Physical exam login to view 8 more bullets studies Imaging for staging Lymph node biopsy login to view 6 more bullets Differential Diagnosis Non-Hodgkin lymphoma AIDS-related lymphadenopathy Infection Breast cancer Cat-scratch fever Treatment Based on staging Localized disease or early stage login to view 3 more bullets Late stage disease or anyone with B symptoms login to view 5 more bullets Complications Tumor lysis syndrome login to view 4 more bullets SVC syndrome Minimal change disease Paraneoplastic syndromes login to view 1 more bullet From treatment login to view 6 more bullets Prognosis > 80% with treatment login to view 4 more bullets 5-30% chance of relapse