Updated: 12/27/2021

Vaginal Cancer

0%
Topic
Review Topic
0
0
N/A
N/A
Questions
2
0
0
0%
0%
Evidence
3
0
0
Topic
Images
https://upload.medbullets.com/topic/120460/images/vaginalca.jpg
  • Snapshot
    • A 62-year-old women presents with abnormal vaginal bleeding. She underwent menopause at the age of 50. Pelvic examination is unremarkable. Vaginal cytology is abnormal, and she undergoes vaginal colposcopy. A biopsy is taken which is positive for vaginal squamous cell carcinoma.
  • Introduction
    • Overview
      • malignancy affecting the vagina
        • most common histologic type is squamous cell carcinoma
          • most commonly secondary to squamous cell carcinoma of the cervix
  • Epidemiology
    • Incidence
      • comprises ~3% of all malignancies involving the female genital tract
      • mean age of diagnosis is ~60 years
    • Risk factors
      • human papillomavirus (HPV) infection
      • extension from malignant cervical disease
      • diethylstilbestrol (DES)
        • associated with adenocarcinoma of the vagina
  • Presentation
    • Symptoms
      • vaginal bleeding (most common)
        • may be postcoital, intermenstrual, or postmenopausal
    • Physical exam
      • vaginal mass may be noted
  • Studies
    • Lab studies
      • vaginal cytology
    • Invasive studies
      • vaginal colposcopy
        • indication
          • performed if cytology is abnormal
      • vaginal biopsy
        • indication
          • confirms the diagnosis
    • Histology
      • squamous cell carcinoma
        • most common histological type
      • clear cell adenocarcinoma
        • secondary to DES exposure in utero
        • typically presents in women < 20 years of age
      • sarcoma botryoides ("botrys" is Greek for "grapes")
        • affecting girls < 4 years of age
        • appears as a polypoid (or grape-like) mass that emerges from the vagina
        • contains spindle-shaped cells and are positive for desmin
  • Differential
    • Cervical cancer
      • differentiating factors
        • evidence of dysplastic or malignat cells in the cervix only
  • Treatment
    • Treatment planning should be individualized depending upon the location, size, and clinical stage of the tumor
  • Complications
    • Treatment-related complications
      • rectal and vaginal strictures
      • urethral, bladder, and/or rectal injury

Please rate this review topic.

You have never rated this topic.

Thank you. You can rate this topic again in 12 months.

Flashcards (0)
Cards
1 of 0
Questions (2)
Question locked
Sorry, this question is for
PEAK Premium Subscribers only
Upgrade to PEAK
Question locked
Sorry, this question is for
PEAK Premium Subscribers only
Upgrade to PEAK
Evidence (3)
EXPERT COMMENTS (0)
Private Note