Snapshot A 43-year-old man presents to the clinic with complaints of a palpable mass at the neck. He denies any fever, chills, night sweats, or pain at the lesion. He is otherwise healthy and denies smoking or drug use. The patient reports 5 sexual partners within the last month. Introduction Overview login to view 1 more bullet Epidemiology Demographics login to view 3 more bullets Risk factors login to view 6 more bullets ETIOLOGY Pathogenesis login to view 5 more bullets Associated conditions login to view 1 more bullet Presentation Symptoms login to view 5 more bullets Physical exam login to view 2 more bullets Imaging All imaging modalities are used in the staging process to assess the degree of local infiltration, lymph node involvement, and presence of distant metastases or second primary tumors Computed tomography (CT) login to view 3 more bullets Magnetic resonance imaging (MRI) login to view 3 more bullets Positron emission tomography (PET) login to view 3 more bullets Studies Labs login to view 3 more bullets Invasive studies login to view 8 more bullets Differential Oral syphilis login to view 3 more bullets Oral tuberculosis login to view 2 more bullets Treatment Nonoperative login to view 6 more bullets Operative login to view 6 more bullets Prognosis Tumors associated with HPV tend to respond well to treatment Complications Metastasis Airway/esophageal obstruction Death