Snapshot A 60-year-old man presents to his primary care physician reporting unintentional weight loss, night sweats, and fevers. He complains of a “strange” rash on his face that bothers him cosmetically. The rash does not hurt or itch. On exam, there are multiple well-demarcated red or purple macules and papules. He has a history of risky behaviors, including IV drug use and unprotected intercourse with multiple partners. His CD4 count comes back at 100/mm3. Introduction Malignancy of lymphatic endothelial cells Commonly affects login to view 4 more bullets epidemiology Epidemiological subsets login to view 13 more bullets etiology Pathogenesis login to view 2 more bullets Presentation Symptoms login to view 3 more bullets Physical exam login to view 6 more bullets Differential Diagnosis Melanoma Bacillary angiomatosis Pyogenic granuloma diagnosis Diagnosis by clinical exam Diagnosis confirmed with skin biopsy login to view 1 more bullet Do CD4 count if AIDS is suspected Treatment Prevention login to view 2 more bullets Anti-retroviral therapy login to view 1 more bullet Injection of vincristine or interferon If the above fail login to view 5 more bullets Discontinue any immunosuppressants Complications Metastatic progression Prognosis Slow progression