Snapshot A 62-year-old man presents to the emergency room with headaches, fevers, and generalized malaise for the past week. His latest visit to the HIV clinic reveals a CD4+ cell count of 50. He has had issues with insurance and has not been on his HIV medications. A lumbar puncture is performed and yeast with clear halos is seen with India ink stain. He is started immediately on the appropriate medications. Introduction Classification login to view 8 more bullets Epidemiology Risk factors login to view 6 more bullets ETIOLOGY Pathogenesis login to view 1 more bullet Presentation Symptoms login to view 4 more bullets Physical exam login to view 3 more bullets Imaging Brain computed tomography (CT) or magnetic resonance imaging (MRI) login to view 6 more bullets Studies Labs login to view 10 more bullets Making the diagnosis login to view 1 more bullet Differential Bacterial meningitis login to view 3 more bullets Treatment Management approach login to view 2 more bullets Medical login to view 12 more bullets Complications Disseminated disease affecting the skin, bones, joints, and lungs Prognosis Without treatment, the infection leads to death With treatment, mortality rate is ~20%