Snapshot A 50-year-old woman presents to her primary care physician for a rash. She describes her past year of backpacking throughout the world including multiple areas of Southeast Asia. She states that her face feels thicker than normal and that she has developed a rash throughout her body. On physical exam, she has leonines facies with thickened earlobes, cheeks, and eyebrows. There are also diffuse nodular and plaque-like lesions with hypopigmentation and non-defined borders. She is counselled on the need for long-term antibiotics. Introduction Classification login to view 6 more bullets Associated conditions login to view 3 more bullets Epidemiology Incidence login to view 1 more bullet Location login to view 1 more bullet Risk factors login to view 3 more bullets ETIOLOGY Pathogenesis login to view 10 more bullets Presentation Symptoms login to view 4 more bullets Physical exam login to view 16 more bullets Studies Labs login to view 2 more bullets Biopsy or slit-skin smear login to view 2 more bullets Making the diagnosis login to view 1 more bullet Differential Morphea login to view 2 more bullets Vitiligo login to view 2 more bullets Treatment Medical login to view 6 more bullets Complications Permanent nerve impairment Deformities Prognosis Slow progression that may develop over months or years May have intermittent acute leprosy reactions Lepromatous type is more severe