Snapshot A 35-year-old man presents to the local urgent care clinic in South America. He is completing a graduate school exchange program, studying tropical ecosystems and is bitten by mosquitoes almost every day. He reports a 3-day history of high fevers, chills, and myalgias. This morning, he noticed some blood in his urine and while blowing his nose. On physical exam, there is gingival bleeding. Laboratory evaluation reveals a mild transaminitis, thrombocytopenia, and hematuria. Introduction Classification login to view 5 more bullets Associated conditions login to view 1 more bullet Epidemiology Incidence login to view 1 more bullet Risk factors login to view 1 more bullet ETIOLOGY Pathogenesis login to view 2 more bullets Presentation Symptoms login to view 3 more bullets Physical exam login to view 15 more bullets Studies Labs login to view 11 more bullets Making the diagnosis login to view 1 more bullet Differential Yellow fever login to view 2 more bullets Zika virus infection login to view 3 more bullets Chikungunya login to view 2 more bullets Treatment Management approach login to view 1 more bullet Conservative login to view 7 more bullets Complications Shock Death Prognosis Symptoms occur after 4-10 days If untreated, mortality rates can be 20% If treated, mortality rate is 2-5% in severe cases