Snapshot A 26-year-old man presents to his primary care physician for weakness in his legs. He had recently spent spring break in the Caribbean exploring jungles and caves and had multiple bug bites from this trip. He recalls a febrile illness with an itchy rash and conjunctivitis that occured shortly after this trip. A few days ago he experienced bilateral weakness in his extremities with occasional foot drop and difficulty walking. He reports no difficulty breathing. On physical exam, he has no fever and no rash. His lower extremities have depressed bilateral deep tendon reflexes and 3/5 in strength. His sensation is intact. He is admitted for monitoring and treatment for this complication of a viral illness. Introduction Classification login to view 5 more bullets Associated conditions login to view 2 more bullets Epidemiology Incidence login to view 3 more bullets Risk factors login to view 3 more bullets ETIOLOGY Pathogenesis login to view 3 more bullets Presentation Symptoms login to view 6 more bullets Physical exam login to view 8 more bullets Studies Labs login to view 5 more bullets Making the diagnosis login to view 1 more bullet Differential Dengue fever login to view 2 more bullets Treatment Conservative login to view 7 more bullets Complications Permanent neurologic damage Guillain-Barré syndrome Prognosis Most infections are asymptomatic If symptomatic, the disease will occur 3-12 days after exposure login to view 1 more bullet If vertically transmitted, fetuses often have microcephaly, intracranial calcifications, and cerebral malformation