Snapshot A 25-year-old woman presents to the clinic for routine check-up. She reports that about a month ago, she had what she thought was mononucleosis. She had fevers, chills, a red rash, muscle pain, and joint pains. She works in a daycare center, and some of her colleagues had similar symptoms. This resolved in 1 week. Today, there are no significant findings on physical exam. Laboratory evaluation reveals that she is positive for CMV-specific immunoglobulin M. Other laboratory tests are negative. Introduction Classification login to view 4 more bullets Associated conditions login to view 1 more bullet Epidemiology Incidence login to view 1 more bullet Risk factors login to view 6 more bullets ETIOLOGY Pathogenesis login to view 3 more bullets Presentation Symptoms login to view 12 more bullets Physical exam login to view 4 more bullets Studies Labs login to view 9 more bullets Histology login to view 1 more bullet Imaging login to view 1 more bullet Making the diagnosis login to view 1 more bullet Differential Epstein-Barr viral (EBV) mononucleosis login to view 3 more bullets Treatment Management approach login to view 1 more bullet Conservative login to view 5 more bullets Medical login to view 7 more bullets Complications Thrombosis Colitis Permanent vision changes Prognosis Often self-limited in immunocompetent patients