Snapshot A 68-year-old woman presents to the emergency department due to fatigue, malaise, and a subjective fever. Her symptoms began approximately 1 week ago. Medical history is significant for small cell lung cancer recently treated with doxorubicin plus cyclophosphamide and etoposide. Her temperature is 102°F (38.9°C) and blood pressure is 100/80 mmHg. A complete blood count with differential is remarkable for an absolute neutrophil count of 320 cells/mm3. She is admitted to the hospital and administered intravenous cefepime. Introduction Definition login to view 2 more bullets Epidemiology Incidence login to view 1 more bullet ETIOLOGY Pathophysiology login to view 1 more bullet Presentation Symptoms/physical exam login to view 3 more bullets Studies Initial testing includes login to view 5 more bullets Other studies login to view 3 more bullets Treatment Medical login to view 13 more bullets Complications Sepsis syndrome Death Prognosis Delayed or inadequate empiric antibiotics leads to worse outcomes