Snapshot A 45-year-old woman presents to her primary care physician for months of fatigue and generalized pruritus. She had been already examined in the dermatology clinic, when scabies and tinea were ruled out. On physical exam, she is noted to be jaundiced with scleral icterus and mild hepatomegaly. Laboratory results reveal a mild transaminitis and positive anti-mitochondrial antibodies but negative anti-nuclear antibody and anti-smooth-muscle antibodies. She is started on ursodeoxycholic acid and scheduled for an ultrasound to evaluate her hepatobiliary system. Introduction Overview login to view 2 more bullets Associated conditions login to view 6 more bullets Epidemiology Demographics login to view 2 more bullets Risk factors login to view 1 more bullet ETIOLOGY Pathogenesis login to view 3 more bullets Presentation Symptoms login to view 8 more bullets Physical exam login to view 4 more bullets Imaging Ultrasound login to view 7 more bullets ERCP (endoscopic retrograde cholangiopancreatography) login to view 5 more bullets Studies Serum labs login to view 13 more bullets Invasive studies login to view 6 more bullets Diagnosis with 2 or more of login to view 3 more bullets Differential Hemochromatosis login to view 2 more bullets Wilson disease login to view 3 more bullets Treatment Lifestyle login to view 2 more bullets Medical login to view 6 more bullets Surgical login to view 4 more bullets Complications Portal hypertension Cirrhosis Osteoporosis login to view 2 more bullets