Review Question - QID 108903

A 46-year-old woman presents to her primary care provider for itching. She reports that she has always had dry skin but that the itching has gotten significantly worse over the last few years. The patient also endorses fatigue and dull abdominal pain. Her past medical history includes Hashimoto thyroiditis, mitral valve prolapse, and osteoarthritis. She takes levothyroxine and ibuprofen for pain in her knees. The patient drinks 2-3 beers per week. She has a 10-pack-year smoking history but quit 15 years ago. She denies any family history of cancer. Her temperature is 98.6°F (37°C), blood pressure is 118/74 mmHg, pulse is 91/min, and respirations are 12/min. On physical exam, her sclera are anicteric. Her abdomen is soft and tender to palpation in the right upper quadrant. Her bowel sounds are normal and hepatomegaly is present. A right upper quadrant ultrasound shows no evidence of extrahepatic biliary dilation. Laboratory studies are performed which reveal the following:

Aspartate aminotransferase (AST): 76 U/L
Alanine aminotransferase (ALT): 57 U/L
Alkaline phosphatase: 574 U/L
Total bilirubin: 1.6 mg/dL

This patient is most likely to have which of the following additional findings?