Snapshot A 34-year-old man presents to his gastroenterologist's office complaining of worsening fatigue, jaundice, and pruritis over the last 2 months. He was diagnosed with ulcerative colitis 8 years ago. The physician ordered labs which came back with an elevated ALP, GGT, and bilirubin. She then scheduled the patient for magnetic resonance cholangiography and pancreatography which revealed multifocal stricturing of both the intrahepatic and extrahepatic biliary system. He is prescribed ursodeoxycholic acid. Introduction Clinical definition login to view 1 more bullet Genetics login to view 2 more bullets Associated conditions login to view 1 more bullet Epidemiology Demographics login to view 2 more bullets Risk factors login to view 3 more bullets ETIOLOGY Pathogenesis login to view 3 more bullets Presentation Symptoms login to view 10 more bullets Physical exam login to view 5 more bullets imaging Magnetic resonance cholangiography/pancreatography (MRCP) login to view 2 more bullets Endoscopic retrograde cholangiography/pancreatography (ERCP) login to view 2 more bullets Studies Diagnostic testing login to view 11 more bullets Differential Primary biliary cirrhosis login to view 5 more bullets Secondary cirrhosis login to view 1 more bullet Primary cholangiocarcinoma login to view 2 more bullets Treatment Management approach login to view 2 more bullets First-line login to view 5 more bullets Other treatments login to view 5 more bullets Complications Cirrhosis and end-stage liver disease login to view 1 more bullet GI and hepatobiliary Mmalignancy login to view 5 more bullets Ascending cholangitis login to view 1 more bullet Fat-soluble vitamin deficiencies login to view 1 more bullet