Snapshot A 23-year-old female presents to the clinic for bloody diarrhea and abdominal pain for the past week. The pain is reported as intermittent, 7/10, and concentrated at the lower left quadrant (LLQ). She denies any rectal pain, trauma, or abnormal ingestions. She endorses subjective fever. A physical examination is unremarkable. A colonoscopy reveals friable rectal mucosa that bleeds easily on contact. Introduction Clinical definition login to view 4 more bullets Associated conditions login to view 14 more bullets Epidemiology Demographics login to view 2 more bullets Risk factors login to view 3 more bullets ETIOLOGY Pathogenesis login to view 11 more bullets Presentation Symptoms login to view 7 more bullets Physical exam login to view 3 more bullets imaging Abdominal radiograph login to view 2 more bullets Barium enema login to view 2 more bullets Computed tomography (CT) or magnetic resonance imaging (MRI) login to view 1 more bullet Colonoscopy with biopsy login to view 8 more bullets Studies Diagnostic testing login to view 8 more bullets Differential Crohn disease login to view 2 more bullets Infectious colitis login to view 2 more bullets Treatment Management of the disease is dependent on the disease severity and extent of involvement First-line login to view 7 more bullets Second-line login to view 2 more bullets Third-line login to view 3 more bullets COMPLICATIONS Anemia Bleeding/hemorrhage Perforation Toxic megacolon Colorectal cancer login to view 1 more bullet Osteoporosis Strictures