Snapshot A 30-year-old man presents to the emergency department with severe, colicky left flank pain of acute onset that radiates to the left groin. He also reports urinary frequency and urgency. Physical examination is significant for left-sided costovertebral angle tenderness. Urine dipstick is heme positive. Urinalysis also shows envelope-shaped crystals. A non-contrast abdominal CT is shown. Introduction Clinical definition calculi (stones) affecting the kidneys; however, these stones can also affect the ureter Nephrolithiasis StonesStone TypeEtiologyImaging Finding(s)Stone ShapeTreatmentCalciumHypercalciuriae.g.,idiopathic hypercalcemiaHypocitraturiaprecipitates calcium oxalate stonesEthylene glycol (antifreeze)Vitamin C abuseCrohn diseaseUrine alkalinizationprecipitates calcium phosphate stonesRadiographyradiopaqueComputerized tomographyradiopaqueEnvelope or dumbbell shapecalcium oxalateWedge-shaped prismcalcium phosphateHydrochlorothiazideCitrateLow-sodium dietCystineImpaired cystine reabsorption in the proximal convoluted tubulethis results in cystinuriaPrecipitates in acidic urineDiagnosiscyanide-nitroprusside testRadiographyradiopaqueComputerized tomographyvisible at timesHexagonalDietary modificationlow sodiumUrine alkalinizationChelating agentsin refractory casesStruvite (magnesium ammonium phosphate)Urease-positive organisms such asProteus mirabilisStaphylococcus saphrophryticusKlebsiellaUrease-positive organisms subesequently alkalinize the urinethis causes struvite stones due to precipitationRadiographyradiopaqueComputerized tomographyradiopaqueCan result in a staghorn calculiCoffin lidRemoval of underlying infectionSurgical removal of the stoneUric acidHyperuricemiae.g., states of increased cell turnover and goutPrecipitates in acidic urineRadiographyradiolucentComputerized tomographyminimally visibleRhomboid/rosetteUrine alkalinizationAllopurinolAdequate hydration prior to chemotherapy treatment Epidemiology Prevalence 12% in men and 7% in women Risk factors hyperparathyroidism hypocitraturia sarcoidosis hyperoxaluria renal tubular acidosis type I nephrocalcinosis cystic fibrosis hyperuricosuria indwelling catheter urinary tract infections malabsorption (e,g., Crohn disease) horseshoe kidney obesity low fluid intake gout medications e.g., allopurinol, indinavir, acetazolamide, and topiramate Etiology Pathogenesis substance precipitation affecting the kidney and ureter e,g., hypercalciuria and low urine volume forms calcium cystals Presentation Symptoms colicky flank pain pain may radiate to the groin or lower abdomen dysuria urgency and frequency Physical exam low abdominal tenderness costovertebral angle (CVA) tenderness Imaging Renal ultrasound indication in patients who are pregnant and children who are suspected to have nephrolithiasis modality abdomen and pelvis to visualize the kidney and bladder Non-contrast computerized tomography (CT) indication preferred imaging for most adults presenting with signs and symptoms concerning for nephrolithiasis modality abdomen and pelvis Studies Labs serum creatinine, uric acid, and ionized calcium should be obtained urine studies urinalysis/dipstick in order to check for red and white blood cells, nitrites, and urine pH urine culture stone composition analysis perform in patients who developed their first stone straining the urine Diagnostic criteria based on clinical presentation and confirmed by imaging Differential Urinary tract infections Acute pyelonephritis Groin hernia Treatment Medical analgesia, bed rest, and intravenous fluids indication considered first-line treatment for uncomplicated urolithiasis < 10 mm α-blockers or calcium channel blockers indication can be considered to facilitate the passage of ureteral stones appears to relax the ureter Operative extracorporal shock wave lithotripsy indication preferred for renal stones < 2 cm percutaneous nephrolithotomy indication preferred for renal stones > 2cm note flexible ureterorenoscopy can be an option if percutaneous nephrolithotomy cannot be done Complications Ureteral obstruction Ureteral stricture Urinary tract infection Renal deterioration Prognosis Small stones are more likely to spontaneously pass
QUESTIONS 1 of 5 1 2 3 4 5 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (M2.RL.17.71) A 31-year-old obese Caucasian female presents to the Emergency Department late in the evening for left lower quadrant pain that has progressively worsened over the last several hours. She describes the pain as sharp and shooting, coming and going. Her last bowel movement was this morning. She has also had dysuria and urgency. Her surgical history is notable for gastric bypass surgery 2 years prior and an appendectomy at age 9. She is sexually active with her boyfriend and uses condoms. Her temperature is 99.5 deg F (37.5 deg C), blood pressure is 151/83 mmHg, pulse is 86/min, respirations are 14/minute, BMI 32. On physical exam, she has left lower quadrant tenderness to palpation with pain radiating to the left groin and left flank tenderness on palpation. Her urinalysis shows 324 red blood cells/high power field. Her pregnancy test is negative. What of the following is the next best step in management? QID: 104613 Type & Select Correct Answer 1 A KUB (kidneys, ureters and bladder) plain film 25% (2/8) 2 Intravenous pyelogram 12% (1/8) 3 Transvaginal ultrasound 0% (0/8) 4 Noncontrast CT scan 62% (5/8) 5 Exploratory laparoscopy 0% (0/8) M 6 Question Complexity C Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 4 Review Tested Concept Review Full Topic Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK
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