Updated: 12/17/2021

Octreotide

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  • Snapshot
    • A 50-year-old woman presents to her dermatologist for a rash of 1 week duration. She is noted to have erosions with crusting of the advancing edge, glossitis, and angular cheilitis. Her dermatologist notes that this rash is consistent with necrolytic migratory erythema, a condition seen in patients with glucagonomas. On laboratory evaluation, the patient has hyperglycemia and increased levels of glucagon. She is referred to oncology and started on octreotide.
  • Introduction
    • Drugs
      • octreotide
    • Mechanism of action
      • octreotide is a somatostatin analog
        • inhibits secretion of splanchnic vasodilatory hormones
          • growth hormone
          • gastrin
          • vasoactive intestinal peptide (VIP)
          • glucagon
          • secretin
          • serotonin
          • pancreatic polypeptide
    • Clinical use
      • acute variceal bleeds
      • acromegaly
      • VIPoma
      • carcinoid tumors
      • glucagonoma
      • other neuroendocrine tumors
    • Adverse effects
      • gastrointestinal upset
      • steatorrhea
      • inhibits cholecystokinin, which increases the risk of cholelithiasis and cholecystitis
      • bradycardia

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