Updated: 12/17/2021

Ondansetron

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  • Snapshot
    • A 60-year-old man with a past medical history of psoriasis, hypertension, and diabetes presents to the emergency room for nausea and vomiting. He has 3 episodes of nonbloody, non-bilious emesis. An electrocardiogram shows that he has borderline prolonged QT interval. His physician would like to give him an anti-emetic, but decides to avoid ondansetron due to its QT prolongating effect.
  • Introduction
    • Drugs
      • ondansetron
    • Mechanism of action
      • serotonin (5-HT3) receptor antagonist, which decreases vagal stimulation
    • Clinical use
      • anti-emesis
        • particularly in the setting of chemotherapy or procedure
    • Adverse effects
      • QT prolongation
      • serotonin syndrome
      • headache
      • constipation

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