Topic
Review Topic
0
0
Snapshot
  • A 50-year-old man presents to his primary care physician for his annual examination. He has a history of hypertension, managed with lifestyle modification but is otherwise healthy and not taking any medication. He reports that his only concern today is that he develops some acid reflux after eating heavy or spicy foods. This occurs especially after he lies down after a big meal. He is instructed to use an over-the-counter antacid, such as calcium carbonate, as needed.
Introduction
  • Drugs
    • aluminum hydroxide
    • calcium carbonate
    • magnesium hydroxide
  • Mechanism of action
    • neutralizes acid in the stomach
    • delays gastric emptying
Antacids

Aluminum Hydroxide
Calcium Carbonate
Magnesium Hydroxide
Mechanism of Action
  • Neutralizes acid in the stomach
  • Delays gastric emptying
  • Also acts as a phosphate binder
  • Promotes osmotic retention of fluid and induces diarrhea
Clinical Use
  • Acid reflux
  • Peptic ulcer disease
  • Aluminum hydroxide

  • Hyperphosphatemia
  • Calcium supplementation
  • Constipation
Adverse effects
  • Constipation
  • Decreased phosphate
    • muscle weakness
    • osteodystrophy
  • Milk-alkali syndrome
    • ↑ calcium
    • in severe cases, can cause metastatic calcification and renal failure
  • Can chelate and decrease the efficacy of some drugs, particularly tetracyclines (doxycycline, tetracycline, and minocycline)
  • Diarrhea
  • Hypotension
  • Cardiac arrest
 
 
 

Please rate topic.

Average 5.0 of 2 Ratings

Thank you for rating! Please vote below and help us build the most advanced adaptive learning platform in medicine

The complexity of this topic is appropriate for?
How important is this topic for board examinations?
How important is this topic for clinical practice?
Topic COMMENTS (0)
Private Note