Snapshot A 35-year-old man presents to his primary care physician for routine check-up. During this visit, review of systems reveals that he has been feeling excessively fatigued with weight loss, lack of energy, and vague abdominal discomfort. He has a history of alcohol abuse as well as acute hepatitis. On physical exam, he has mild tenderness to palpation and no hepatomegaly. Laboratory evaluation shows elevated liver enzymes and positive anti-HCV antibodies. Introduction Overview login to view 1 more bullet Associated conditions login to view 1 more bullet Epidemiology Risk factors login to view 4 more bullets etiology Hepatitis C virus (most common) Hepatitis B virus with or without hepatitis D coinfection Nonalcoholic steatohepatitis Alcoholic hepatitis Autoimmune hepatitis Alpha-1-antitrypsin deficiency Wilson disease Hemochromatosis Medications, when taken long term login to view 3 more bullets Pathogenesis login to view 3 more bullets Presentation History login to view 1 more bullet Symptoms login to view 5 more bullets Physical exam login to view 4 more bullets Imaging Ultrasound of liver login to view 4 more bullets Studies Serum labs login to view 12 more bullets Invasive studies login to view 2 more bullets Differential Acute hepatitis login to view 2 more bullets Treatment Management approach login to view 2 more bullets Lifestyle login to view 2 more bullets Medical login to view 12 more bullets Surgical login to view 3 more bullets Complications Cirrhosis Hepatocellular carcinoma Portal hypertension