Snapshot A 33-year-old woman delivers a baby girl at full-term without complications. During a breastfeeding session, a lactation specialist notes that the neonate has poor muscle tone, poor suck, and a weak cry. Her basic laboratory results are normal. As hypotonia is classically associated with a genetic condition, a geneticist is consulted for further discussion. Introduction Overview login to view 1 more bullet Epidemiology Incidence login to view 1 more bullet ETIOLOGY Pathogenesis login to view 2 more bullets Genetics login to view 6 more bullets Associated conditions login to view 1 more bullet Presentation Symptoms login to view 3 more bullets Physical exam login to view 15 more bullets Imaging Radiograph login to view 4 more bullets Studies Serum labs login to view 3 more bullets Genetic testing login to view 2 more bullets Differential Angelman syndrome login to view 3 more bullets Treatment Lifestyle login to view 5 more bullets Medical login to view 7 more bullets Surgical login to view 3 more bullets Complications Hypopituitarism with deficiency in growth hormone Scoliosis Obstructive sleep apnea Cor pulmonale Prognosis Patients are typically able to function well into adulthood