Updated: 1/1/2022

Table of Other Immunodeficiencies

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Topic
  • Overview - STEP I Review
    • Brutons Agammaglobulinemia
    • Severe Combined Immunodeficiency (SCID)
    • Wiskott-Aldrich Syndrome
    • Ataxia-telangiectasia
    • Selective Immunoglobulin Deficiency
    • Chediak-Higashi Syndrome
    • DiGeorge syndrome
      • Immunodeficiency caused by thymic hypoplasia/aplasia
      • Patients present with reduced number of T cells
    • Job's Syndrome
    • Transient hypogammaglobinemia of infancy
    • Hyper IgM syndrome
    • Complement pathway deficiencies

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(M2.RH.15.4678) A 3-year-old male is brought to the pediatrician for a check-up. The patient has a history of recurrent ear infections and several episodes of pneumonia. His mother reports the presence of scaly skin lesions on the face and in the antecubital and popliteal fossa since the patient was 2 months old. Physical examination also reveals bruising of the lower extremities and petechiae distributed evenly over the boy's entire body. A complete blood count reveals normal values except for a decreased platelet count of 45,000/mL. Which of the following findings would be expected on follow-up laboratory work-up of this patient's condition?

QID: 107249

Decreased CD18 expression on flow cytometry

8%

(2/26)

Decreased CD43 expression on flow cytometry

46%

(12/26)

Decreased CD8/CD4 ratio on flow cytometry

12%

(3/26)

Increased IgM on quantitative immunoglobulin serology

12%

(3/26)

Decreased IgE on quantitative immunoglobulin serology

19%

(5/26)

M 8 E

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Evidence (3)
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EXPERT COMMENTS (4)
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