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A 16-year-old male presents to his pediatrician with complaints of malaise, fatigue, sore throat, and fever over the last several days. His vital signs are as follows: T 39.1 C, HR 82, BP 122/76, RR 14, and SpO2 99%. Physical examination is significant for splenomegaly, tonsillar exudate, and posterior auricular lymphadenopathy. The tonsils are not notably enlarged. Laboratory work-up shows an elevated lymphocyte count, atypical lymphocytes on a peripheral blood smear, and a positive heterophile antibody screen. Which of the following is the best management of this patient's condition?
Bed rest and activity limitation
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A 17-year-old young man presents to his physician complaining of 2 days of fatigue, subjective fever, and a sore throat. His symptoms have been persistent during this time frame. He is sexually active but states that he uses condoms. He smokes marijuana daily and drinks alcohol on the weekends. His temperature is 100°F (37.8°C), blood pressure is 117/84 mmHg, pulse is 110/min, respirations are 16/min, and oxygen saturation is 98% on room air. Physical exam is notable for posterior cervical lymphadenopathy, splenomegaly, and the finding in Figure A. An initial rapid streptococcus antigen test is negative. What is the most appropriate management of this patient?
Heterophile antibody test
Peripheral blood smear