Snapshot A male neonate is born to a G2P2 mother who works at an animal shelter. She constantly interacted with cats, dogs, and rabbits. The neonate is noted to be jaundiced with hepatosplenomegaly. An ultrasound of his head shows hydrocephalus, and a subsequent CT scan shows intracranial calcifications. Out of concern for a congenital infection, his blood is sent for serologic testing for Toxoplasma. Introduction Overview login to view 1 more bullet Epidemiology Demographics login to view 1 more bullet Risk factors login to view 3 more bullets ETIOLOGY Pathogenesis login to view 3 more bullets Presentation History login to view 1 more bullet Symptoms login to view 2 more bullets Physical exam login to view 8 more bullets Imaging Fetal ultrasound login to view 2 more bullets CT head login to view 2 more bullets Studies Serum labs login to view 2 more bullets Differential ToRCHeS differential ToRCHeS Congenital Infections Toxoplasmosis Hydrocephalus, intracranial calcifications, and chorioretinitis +/- blueberry muffin rash Rubella Blueberry muffin rash, cataracts, deafness, and cardiac defects CMV Sensorineural deafness, microcephaly, periventricular calcifications, seizures, and petechial rash with thrombocytopenia Herpes Vesicular rash, keratoconjunctivitis, and acute meningoencephalitis Syphillis Facial abnormalities (such as rhagades, or linear scars at the oral commissure, saddle nose, and notched teeth), saber shins, and deafness Stillbirth Treatment Medical login to view 6 more bullets Complications Death Severe neurologic sequelae Prognosis Mortality is high with congenital toxoplasmosis