Updated: 12/2/2021

Aromatase Inhibitors

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  • Snapshot
    • A 59-year-old woman with recently diagnosed metastatic estrogen-receptor (ER) positive and human epidermal growth factor 2 (HER2) negative breast cancer presents for follow-up care. She is hormone therapy naive and has non-visceral involvement of the cancer. She is started on letrozole.
  • Introduction
    • Mechanism of action
      • inhibits peripheral conversion of androgens to estrogens via aromatase inhibition
    • Clinical use
      • estrogen-receptor positive breast cancer
        • first-line treatment in postmenopausal women to prevent recurrence
    • Toxicity
      • menopausal symptoms
      • fatigue
    • Medications
      • letrozole
      • anastrozole
      • exemestane
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