Review Question - QID 216375

A physician is treating 2 patients with breast cancer who have undergone surgery and are being evaluated for adjuvant endocrine treatment.

Patient A is a 61-year-old woman with T2N0M0 invasive ductal carcinoma of the right breast treated with breast-conserving therapy. Menarche was at 11. Her past medical history is significant for obesity. Her temperature is 98.6°F (37.0°C), blood pressure is 120/80 mmHg, pulse is 70/min, respirations are 12/min, and body mass index (BMI) is 41 kg/m^2. The pathology report shows the following:

Estrogen receptor (ER): Positive (>95%, 3+)
Progesterone receptor (PR): Positive (70%, 2+)
Human epidermal growth factor receptor 2 (HER2): Negative (1+) by immunohistochemistry (IHC) technique

Patient B is a 38-year-old woman with T1cN0M0 invasive ductal carcinoma of the left breast treated with mastectomy. Menarche was at 12. Her past medical history is significant for ruptured bilateral tubo-ovarian abscess treated with bilateral oophorectomy at age 27. Her temperature is 98.6°F (37.0°C), blood pressure is 115/75 mmHg, pulse is 65/min, and respirations are 14/min. The pathology report shows the following:

ER: Positive (>95%, 3+)
PR: Positive (70%, 2+)
HER2: Negative (1+) by IHC technique

Which of the following would be the appropriate adjuvant endocrine treatment for the 2 patients as seen in Figure A?