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Updated: Dec 2 2021


  • Snapshot
    • A 8-year-old Caucasian girl presents to her pediatrician due to breast enlargement, axillary odor, and menarche. Breast examination is suggestive of Tanner stage 3 with axillary hair growth. Pubic hair appears to be Tanner stage 3. After relevant testing, the patient's findings are consistent with central precocious puberty and is started on a gonadotropin-releasing hormon analog.
  • Introduction
    • Mechanism of action
      • a gonadotropin-releasing hormon (GnRH) analog that acts on GnRH receptor resulting in
        • agonism when used in a pulsatile fashion
        • antagonism when used in a continuous fashion
    • Clinical use
      • central precocious puberty
      • endometriosis
      • uterine leiomyomata (fibroids)
      • advanced prostate cancer
        • used as palliative treatment
    • Toxicity
      • edema
      • headache
      • antiandrogen side-effects
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