Snapshot A 80-year-old man presents with a 2-week history of severe pruritus and eczema. His past medical history includes atopic dermatitis, thyroid disease, and multiple sclerosis. On physical exam, he has dozens of 1-2 cm tense bullae and several erosions over his upper and lower extremities. His oral mucosa is not involved. Nikolsky sign is negative. A skin biopsy is taken and anti-BP180 is detected in his blood. A potent topical steroid is prescribed. Introduction Clinical definition login to view 1 more bullet Associated conditions login to view 8 more bullets Epidemiology Demographics login to view 2 more bullets ETIOLOGY Pathogenesis login to view 4 more bullets Presentation Symptoms login to view 2 more bullets Physical exam login to view 11 more bullets Studies Based primarily on clinical presentation and observation Skin biopsy login to view 1 more bullet Immunofluorescence login to view 1 more bullet Complete blood count (CBC) login to view 1 more bullet Differential Pemphigus vulgaris login to view 3 more bullets Treatment Conservative login to view 7 more bullets Medical login to view 14 more bullets Complications Skin and soft tissue bacterial infection of open lesions Prognosis Can resolve spontaneously Often recurs