Snapshot A 45-year-old woman presents to the emergency department for severe pain of her left foot. She states that this has never happened before. Her symptom is accompanied by fever and generalized myalgias. Medical history is significant for type II diabetes mellitus. On physical exam, there is exquisite tenderness to palpation, erythema, palpable crepitus, and tense bullae. Surgery is immediately consulted. Introduction Clinical definition login to view 1 more bullet Epidemiology Risk factors login to view 4 more bullets Etiology Polymicrobial infection login to view 7 more bullets Monomicrobial infection login to view 1 more bullet Pathogenesis login to view 6 more bullets Presentation Symptoms login to view 3 more bullets Physical exam login to view 7 more bullets Imaging Magnetic resonance imaging (MRI) login to view 3 more bullets Studies Labs login to view 3 more bullets Intraoperative studies login to view 2 more bullets Diagnostic criteria login to view 2 more bullets Differential Cellulitis Staphylococcus scalded skin syndrome Gas gangrene Treatment Management approach login to view 1 more bullet Medical login to view 14 more bullets Operative login to view 3 more bullets Prognosis Increased mortality and risk of amputation Complications Streptococcal toxic shock syndrome Compartment syndrome Myositis Muscle necrosis