Snapshot A 25-year-old woman with a history of sarcoidosis presents with fever, fatigue, and joint pain over the past week. Yesterday, she developed a bruise-like and raised painful rash on her shins despite having no recent trauma to the area. Physical exam reveals multiple 2-4 cm erythematous and tender nodules with poorly demarcated borders on her anterior shins. Laboratory examination reveals elevated inflammatory markers. She is sent home with reassurance and instructions to take ibuprofen as needed for pain. Introduction Clinical definition login to view 1 more bullet Associated conditions login to view 10 more bullets Epidemiology Incidence login to view 1 more bullet Demographics login to view 2 more bullets Risk factors login to view 3 more bullets ETIOLOGY Pathogenesis login to view 3 more bullets Presentation Symptoms login to view 5 more bullets Physical exam login to view 6 more bullets Studies Labs login to view 3 more bullets Biopsy login to view 2 more bullets Histology login to view 2 more bullets Differential Scleroderma Granulomas Treatment Management approach login to view 1 more bullet Medical login to view 3 more bullets Complications Arthralgias may persist Secondary bacterial infection Prognosis Erythema nodosum typically resolves spontaneously and fades over 1-2 months