Snapshot A 78-year-old man underwent coronary angiography after a positive stress test. Approximately 48 hours after angiography, routine serum labs were significant for an increased creatine about 50% above baseline. He reports no change in urinary frequency or volume. Medical history is significant for coronary artery disease, chronic kidney disease, and type II diabetes mellitus. Physical examination is unchanged since before the procedure. Introduction Clinical definition acute kidney injury soon (24-48 hours) after contrast media administration Epidemiology Incidence dependent on the presence or absence of risk factors among patients with no risk factors, the risk of contrast nephropathy is less than 1% Risk factors primary chronic kidney disease diabetic nephropathy with renal insufficiency multiple myeloma contrast amount causes of decreased renal perfusion (e.g., hypovolemia) Etiology Pathogenesis contrast media results in acute tubular necrosis via unknown mechanisms Presentation Physical exam oliguria (rare) most patients are non-oliguric Studies Labs serum creatinine increased serum creatine within 1-2 days after contrast administration urinalysis may show evidence of acute tubular necrosis such as muddy brown granular casts epithelial cellular casts Differential Ischemic acute tubular necrosis Acute interstial nephritis Renal atheroemboli Acute kidney injury after angiography which can be distinguished from contrast-induced nephropathy by kidney injury occuring days to weeks after angiography little or no recovery in renal function (frequently) other embolic lesions or livedo reticularis Treatment Conservative prevention indication there is no specific therapy for contrast-induced nephropathy and thus prevention is the best treatment modality using other imaging modalities that do not require contrast if clinically possible using decreased doses of contrast avoiding renotoxic medications and volume depletion intravenous isotonic fluids (e.g., normal saline or sodium bicarbonate) supportive treatment indication in patients that develop acute kidney injury after contrast administration modality regularly monitoring electrolytes, BUN, and creatinine management is similar to acute kiney injury from other causes Complications Residul renal dysfunction Prognosis In the majority of cases over the course of a few days-to-one week the creatine returns to baseline (or close to it)