Snapshot A 2-day-old boy is brought to the emergency department by his mother after he became inconsolable with abdominal distention and has not vomited or passed his first feces. He was born to a 27-year-old woman via spontaneous vaginal delivery without any perinatal complications. The mother was not able to attend prenatal care visits to receive appropriate screening. An abdominal radiograph is performed, which shows dilated loops of bowel without any evidence for perforation. A hyperosmotic contrast enema radiography is performed and confirms meconium ileus. A sweat test is subsequently done to work-up for cystic fibrosis. Introduction Clinical definition login to view 2 more bullets Epidemiology Incidence login to view 1 more bullet Risk factors login to view 4 more bullets ETIOLOGY Pathogenesis login to view 3 more bullets Genetics login to view 9 more bullets Associated conditions login to view 1 more bullet Presentation Symptoms login to view 1 more bullet Physical exam login to view 3 more bullets Imaging Radiographs login to view 6 more bullets Contrast enema login to view 7 more bullets Studies Labs login to view 2 more bullets Differential Diagnosis Intestinal atresia Hirschsprung disease Volvulus Treatment Non-operative login to view 6 more bullets Operative login to view 4 more bullets Complications Complications login to view 4 more bullets Prognosis There is a low mortality risk after appropriate treatment of meconium ileus