Snapshot A 2-year-old girl is brought to her pediatrician’s office for a new rash on the palms and soles that developed yesterday. For the past few days, she has had low-grade fevers and a slight cough, and of note, her 6-year-old sister had similar symptoms. Upon further questioning, she and her sister have had all routine childhood vaccinations. On physical exam, there are multiple 2-3-mm grey vesicular lesions on the bilateral palms and soles and several vesicles and ulcers on the oral mucosa. The physician informs her parents that this disease typically resolves spontaneously and to keep the patient hydrated. Introduction Classification login to view 11 more bullets Epidemiology Incidence login to view 1 more bullet Demographics login to view 1 more bullet Risk factors login to view 4 more bullets ETIOLOGY Pathogenesis login to view 1 more bullet Presentation Symptoms login to view 7 more bullets Physical exam login to view 2 more bullets Studies Labs login to view 2 more bullets Differential Rickettsia rickettsii infection login to view 2 more bullets Chickenpox login to view 2 more bullets DIAGNOSIS Making the diagnosis login to view 1 more bullet Treatment Management approach login to view 1 more bullet Conservative login to view 7 more bullets Complications Aseptic meningitis Guillain-Barre syndrome Prognosis Spontaneously resolves