Snapshot A 27-year-old man presents to the physician with his wife after a referral from a fertility clinic appointment. The couple has been trying to have a baby without success for the past year. The man is tall and lean in stature. On physical examination, the man has sparse, thin hair in the axilla and pubic areas, small, firm testes, and the finding seen in the image. Analysis of his sperm reveals azoospermia. Introduction Overview login to view 1 more bullet Epidemiology Incidence login to view 2 more bullets Risk factors login to view 1 more bullet ETIOLOGY Pathophysiology login to view 6 more bullets Presentation Symptoms login to view 6 more bullets Physical exam login to view 5 more bullets Studies Karyotype login to view 2 more bullets Serum hormone levels login to view 3 more bullets Differential Double Y males (47,XYY) login to view 2 more bullets Fragile X syndrome login to view 2 more bullets Marfan syndrome login to view 2 more bullets Treatment Medical login to view 3 more bullets Lifestyle login to view 3 more bullets Complications ↑ risk of breast cancer login to view 2 more bullets