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A 5-year-old child is brought to his primary care physician for a well-child examination. The child was born when his mother was 43 years old. On physical exam, the child is of small stature, has palpebral fissures that are upward slanting, and inner epicanthal folds. Before proceeding to funduscopic examination, you notice the following in his iris (Figure A). Which of the following is/was most likely present in this child?
Decreased risk of developing acute lymphocytic leukemia
Much later onset of Alzheimer disease
Passed meconium after 48 hours
Hypertonic as an infant
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