Updated: 4/1/2021

Mifepristone / Ulipristal

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  • Snapshot
    • A 30-year-old G2P1 woman presents to her obstetrician’s office to discuss ending her pregnancy at 7 weeks gestation. She reports that her reasons for doing so is personal, and she wishes to avoid surgical procedure. Her obstetrician informs her that there are oral pills available to induce an abortion.
  • Introduction
    • Drugs
      • mifepristone
      • ulipristal
    • Mechanism of action
      • antiprogestins via competitive inhibition of the progesterone receptor
    • Clinical use
      • termination of pregnancy
        • mifepristone + misoprostol (PGE1 analog)
      • emergency contraception
        • ulipristal
          • must be taken within 120 hours of unprotected sex with highest efficacy if taken within 72 hours
    • Adverse effects
      • abdominal pain
      • uterine cramping
      • nausea and vomiting

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