Updated: 4/14/2017

Progestins

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Snapshot
  • A 21-year-old woman presents to her primary care physician for contraceptive options. She is currently sexually active with one man and consistently use condoms. During one episode of intercourse approximately 2 months ago, the condom tore but did not result in her becoming pregnant. She is looking for a reversible form of contraception, but hopes to become pregnant in 6-7 years. After presenting her with various contraceptive options, she agrees to receive the levonorgestrel intrauterine device.
Introduction
  • Mechanism of action
    • cervical mucus thickening
    • suppresses ovulation
    • ↓ endometrial proliferation
    • ↑ maturity/vascularization of endometrium
  • Clinical use
    • hormone contraception
      • can be in the form of a pill, implant device, depot injection, and intrauterine device
    • abnormal uterine bleeding
      • due to hormonal imbalances
    • to treat pain due to endometriosis
    • secondary amenorrhea
      • causes may be due to functional hypothalamic amenorrhea
    • endometrial cancer
  • Toxicity
    • amenorrhea
    • menstrual bleeding
 

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