Updated: 12/3/2021

Progestins

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  • Snapshot
    • A 21-year-old woman presents to her primary care physician for contraceptive options. She is currently sexually active with one man and consistently use condoms. During one episode of intercourse approximately 2 months ago, the condom tore but did not result in her becoming pregnant. She is looking for a reversible form of contraception, but hopes to become pregnant in 6-7 years. After presenting her with various contraceptive options, she agrees to receive the levonorgestrel intrauterine device.
  • Introduction
    • Mechanism of action
      • cervical mucus thickening
      • suppresses ovulation
      • ↓ endometrial proliferation
      • ↑ maturity/vascularization of endometrium
    • Clinical use
      • hormone contraception
        • can be in the form of a pill, implant device, depot injection, and intrauterine device
      • abnormal uterine bleeding
        • due to hormonal imbalances
      • to treat pain due to endometriosis
      • secondary amenorrhea
        • causes may be due to functional hypothalamic amenorrhea
      • endometrial cancer
    • Toxicity
      • amenorrhea
      • menstrual bleeding
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