Snapshot A newborn boy is brought to the emergency room for the evaluation of fever, red skin, and irritability. For the past few days he has been refusing to eat and had minimal urinary output. Vitals signs are significant for a temperature of 100.8°F (38.2°C). On physical examination there is diffuse erythematous non-blanching tender patches. There is also superficial skin sloughing and multiple fragile and flaccid bullae. Superficial wound cultures are sterile. Introduction Clinical definition login to view 1 more bullet Associated Staphylococcus aureus conditions login to view 9 more bullets Epidemiology Incidence login to view 1 more bullet Demographics login to view 1 more bullet Pathophysiology Mechanism of injury login to view 3 more bullets Children are at risk due to naïve immune system Adults at risk usually have underlying immune compromise Presentation Symptoms login to view 2 more bullets Physical exam login to view 7 more bullets Studies Labs login to view 3 more bullets Biopsy login to view 4 more bullets Differential Toxic epidermal necrolysis login to view 1 more bullet Bullous impetigo login to view 3 more bullets Treatment Medical login to view 6 more bullets Complications Secondary infection of denuded skin Prognosis Survival with treatment login to view 2 more bullets