4.5 of 2 Ratings
A 25-year-old woman with no prior medical history presents with complaints of a new skin rash. She was in her usual state of health until one month ago when she began developing an itchy rash on her lower abdomen. The patient works as a fitness instructor. Her family history is notable for a father with psoriasis and a brother with atopic dermatitis. Physical exam is notable for an otherwise healthy-appearing female and Figure A on skin exam. Her temperature is 98.9°F (37.2° C), pulse is 80/min, blood pressure is 120/82 mmHg, respirations are 10/min, and O2 saturation is 99% on room air. Her laboratory results are as follows:Serum:Na+: 135 mEq/LK+: 4.2 mEq/LHCO3-: 25 mEq/LCl-: 100 mEq/LBUN: 19 mg/dLCreatinine: 1.0 mg/dLGlucose: 94 mg/dLHemoglobin: 14.4 g/dLLeukocyte count: 10,000 cells/mm^3Platelet count: 380,000/mm^3Which of the following is the mechanism underlying this patient’s skin findings?
Immune complex-mediated hypersensitivity
Deficiency of filaggrin
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A 20-year-old man presents to his primary care physician complaining of intense itching on the back of his left calf. He states that he noticed a red and blistering rash this morning and does not recall experiencing a similar rash in the past. His social history is notable for a job at the zoo. His temperature is 97.7°F (36.5°C), blood pressure is 120/74 mmHg, pulse is 70/min, respirations are 14/min, and oxygen saturation is 98% on room air. His physical exam is notable for the finding in Figure A. Which of the following findings would be found in the most likely diagnosis?
Extraepidermal vesicles with keratinocytes
Langerhans giant cells