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Updated: Dec 16 2021


Images intertrigo.jpg stain.jpg
  • Snapshot
    • A 70-year-old man presents from his nursing home for an armpit rash. He reports itchiness and some irritation with movement. His medical history includes obesity, diabetes, hypertension, hyperlipidemia, and rheumatoid arthritis. He is currently taking immunosuppressive drugs for his rheumatoid arthritis. Physical exam reveals a 5-cm erythematous plaque with peripheral scales. There are multiple satellite lesions. A skin scraping KOH preparation reveals septated hyphae. He is given topical therapy for his rash.
  • Introduction
    • Clinical definition
      • inflammatory condition of the intertriginous areas (two skin surfaces in close proximity)
        • often caused by superficial infection of Candida spp.
    • Associated conditions
      • persistent candidal infections may indicate immunodeficiency
        • diabetes
        • HIV
  • Epidemiology
    • Demographics
      • children and adults
      • infants
        • candidal diaper dermatitis
    • Location
      • intertriginous regions
    • Risk factors
      • warm and moist environment of skin folds
      • obesity
      • constricting clothing
      • hyperhidrosis
      • incontinence
      • diabetes
  • Etiology
    • Pathogenesis
      • T-cell mediated immunity is used against candidal infections
      • Candida spp. are part of the skin’s normal flora in low numbers
        • can cause infection when
          • the bacterial flora is altered
          • host defenses are impaired
          • trauma, occlusion, or abrasions can disrupt skin integrity
    • Candida spp.
      • unicellular and dimorphic fungus with budding yeast
      • often have septate hyphae and pseudohyphae
      • most common
        • Candida albicans
  • Presentation
    • Symptoms
      • pruritus
      • painful if there is significant maceration
      • easily irritated
    • Physical exam
      • erythematous and macerated plaques
        • “beefy red”
      • erosions with peripheral scaling
      • erythematous satellite papules and pustules
        • classic for candidal cutaneous infections
      • locations
        • inguinal folds
        • axilla
        • intergluteal folds
        • inframammary folds
  • Studies
    • KOH preparation
      • skin scrapings at active edge of lesion mixed with KOH
      • presence of septated hyphae and spores indicates fungal infection
    • Trypan blue stain
      • for rapid diagnosis
    • Fungal culture
      • skin scrapings at edge of lesion
      • indications
        • if there is any doubt about diagnosis
    • Making the diagnosis
      • this is a clinical diagnosis
        • satellite lesions are classic and support the diagnosis of candidal intertrigo
  • Differential
    • Tinea cruris
    • Atopic dermatitis
    • Erythrasma
  • Treatment
    • Conservative
      • weight loss
        • indication
          • prevention of future recurrence
    • Medical
      • topical antifungal therapy
        • indications
          • first-line treatment
          • localized disease
        • drugs
          • nystatin
          • clotrimazole
          • ketoconazole
      • topical corticosteroids
        • indications
          • adjunctive therapy for symptomatic relief
          • should be used with antifungal topical therapies
        • drugs
          • 2% hydrocortisone
      • oral antifungal therapy
        • indications
          • severe and refractory disease
          • widespread disease
        • drugs
          • fluconazole
          • itraconazole
  • Complications
    • Secondary bacterial infection
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