Snapshot A 61-year-old man presents to the emergency department for severe right lower extremity pain. He has a medical history of hypertension, hyperlipidemia, coronary artery disease requiring drug-eluting stents, and type 2 diabetes mellitus. Physical examination is remarkable for a pale right lower extremity, significant weakness and sensory impairment, and absent capillary refill. Arterial Dopplers do not reveal an audible pulse. Vascular surgery was consulted for emergent amputation. Introduction Overview login to view 37 more bullets Epidemiology login to view 6 more bullets Etiology login to view 9 more bullets Associated conditions login to view 2 more bullets Prognosis login to view 1 more bullet Presentation Symptoms/physical examination login to view 7 more bullets Imaging CT angiography or catheter-based arteriography login to view 2 more bullets Transthoracic echocardiogram can be used to confirm cardiac source of systemic embolism login to view 3 more bullets Studies This is a clinical diagnosis that can be supported by imaging Differential Chronic limb ischemia login to view 2 more bullets Phlegmasia login to view 3 more bullets Treatment Medical login to view 6 more bullets Operative login to view 6 more bullets Complications Acute renal failure Hyperkalemia Infection