Snapshot A 45-year-old woman presents to the emergency room for chest discomfort and shortness of breath for the past few hours. She has a past medical history of systemic lupus erythematosus. Physical exam reveals hypotension, muffled heart sounds, distended jugular veins, and positive pulsus paradoxus. An ECG reveals low voltages and electrical alternans. Imaging shows an enlarged cardiac silhouette on radiography. Summary Cardiac Tamponade is a rare condition caused by the accumulation of fluid or blood in the pericardial sac that leads to compression of the heart. The condition typically presents in adults and presents with Beck's triad and pulsus paradoxus. Diagnosis is made clinically with primary symptoms such as chest pain, shortness of breath, and low blood pressure and exam findings including muffled heart sounds and jugular venous distention. Treatment is usually immediate supportive measures including IV fluids, oxygen therapy, and blood pressure stabilizing agents. However, definitive treatment is pericardiocentesis. Operative treatment of pericardiotomy is indicated in refractory pericardial effusion, constrictive pericarditis, and purulent pericarditis. Epidemiology Incidence login to view 11 more bullets Location login to view 2 more bullets Risk factors login to view 8 more bullets Etiology Pathogenesis login to view 9 more bullets Pathoanatomy login to view 3 more bullets Pericardial effusion Hemorrhage into the pericardial sac Iatrogenic Anatomy Pericardium is the membrane that encloses the heart login to view 9 more bullets Presentation Symptoms login to view 4 more bullets Physical exam login to view 20 more bullets Imaging Radiography login to view 6 more bullets Transthoracic echocardiography (TTE) login to view 10 more bullets Computed Tomography (CT) login to view 9 more bullets Cardiovascular Magnetic Resonance (CMR) login to view 10 more bullets Studies Electrocardiogram (ECG) login to view 7 more bullets Labs login to view 15 more bullets Right heart catheterization login to view 4 more bullets Diagnosis Is based on combination of clinical presentation, ECG, echocardiogram, and chest radiography Differential Constrictive pericarditis login to view 6 more bullets Tension pneumothorax login to view 3 more bullets Pericardial effusion login to view 1 more bullet Treatment Goals login to view 1 more bullet Medical login to view 13 more bullets Operative login to view 10 more bullets Techniques Pericardiocentesis login to view 11 more bullets Surgical drainage login to view 10 more bullets Complications Death Prognosis In acute cases, cardiac tamponade can develop rapidly In chronic cases, cardiac tamponade will develop gradually, as the pericardium can adjust slowly to the increased pressure over time