Snapshot A 30-year-old man presents to his physician’s office for intermittent pain in his hands and feet and discoloration of 3 of his fingers, which he says is painful. He has had pain in his extremities for about 1 year now, but this is the first time he’s seen discoloration of his fingers. He has a 20-pack-year smoking history. Introduction Clinical definition login to view 2 more bullets Associated conditions login to view 1 more bullet Epidemiology Demographics login to view 3 more bullets Risk factors login to view 1 more bullet ETIOLOGY Pathogenesis login to view 2 more bullets Presentation Symptoms login to view 4 more bullets Physical exam login to view 9 more bullets Imaging Echocardiography login to view 2 more bullets Studies Laboratory evaluation should be used to exclude other autoimmune diseases Arteriography login to view 5 more bullets Biopsy of involved vessels login to view 2 more bullets Histology login to view 1 more bullet Differential Raynaud phenomenon login to view 2 more bullets Polyarteritis nodosa login to view 2 more bullets DIAGNOSIS Making the diagnosis login to view 1 more bullet Treatment Management approach login to view 2 more bullets Conservative login to view 9 more bullets Operative login to view 5 more bullets Complications Sepsis Need for amputation Prognosis Typically resolves with cessation of smoking Patients who do not stop smoking often eventually undergo amputation