Snapshot A 60-year-old woman presents with chest pain. She reports the chest pain started today and describes it as sharp and brief. When she sits up, the pain improves. She has no significant past medical history but endorses a viral respiratory infection a few days ago. On physical exam, she is in no acute distress. She has a low-grade fever. An electrocardiogram shows widespread ST segment elevation and PR depression in the precordial leads. Summary Pericarditis is a condition that results from inflammation of the pericardium characterized by sharp pain worsened by inhalation. It is most often idiopathic, but often due to viral illness, myocardial infarction, or radiation therapy. Patients present with pleuritic chest pain, usually relieved by sitting forward. Diagnosis is made when MI and pneumonia are ruled out with imaging and ECG, and PR depression is highly specific for pericarditis. X-rays can be normal in many patients, so other modalities like echocardiography and CT can help visualize inflammation and effusion in the pericardium. Treatment is usually pain relief, NSAIDs, and addressing the underlying cause. Operative treatment is indicated when there is an ineffective pharmacological response and in patients with chronic disease. Epidemiology Incidence login to view 5 more bullets Demographics login to view 5 more bullets Etiology Pathophysiology login to view 17 more bullets Associated conditions login to view 10 more bullets Anatomy Pericardium is the membrane that encloses the heart login to view 8 more bullets Presentation History login to view 2 more bullets Symptoms login to view 4 more bullets Physical exam login to view 15 more bullets Imaging Radiographs login to view 6 more bullets Transthoracic Echocardiography login to view 7 more bullets Cardiac CT w/ IV contrast login to view 6 more bullets Cardiac MRI login to view 6 more bullets Studies Serum labs login to view 5 more bullets Electrocardiogram (ECG) login to view 15 more bullets Pericardiocentesis with fluid analysis login to view 7 more bullets Differential Myocardial infarction (MI) login to view 2 more bullets Pneumonia (PNA) login to view 2 more bullets Cardiac tamponade login to view 2 more bullets Diagnosis Acute pericarditis requires 2/4 of the following criteria to be present to diagnose login to view 4 more bullets Treatment Goals login to view 1 more bullet Medical login to view 22 more bullets Surgical login to view 5 more bullets Techniques Pericardiocentesis login to view 9 more bullets Pericardiectomy login to view 9 more bullets Complications Pericardial effusion login to view 5 more bullets Cardiac tamponade login to view 8 more bullets Constrictive pericarditis login to view 9 more bullets Prognosis Overall favorable prognosis login to view 6 more bullets Can recur or develop into chronic pericarditis