Snapshot A 32-year-old woman is brought to the psychiatric emergency department by emergency medical service for a suicidal attempt. The patient expressed to the hospital staff that she wishes to end her life due to concerns someone is attempting to kidnap her. She has a medical history of schizophrenia and has not been adherent to her aripiprazole. The patient attempted to attack 1 of the security guards due to the belief that he is involved in her kidnapping. She was given multiple doses of intramuscular haloperidol. Approximately 2 days later, the patient's temperature is 102°F (38.9°C), blood pressure is 163/95 mmHg, pulse is 115/min, and respirations are 26/min. On physical examination, the patient is diffusely rigid and is profusely diaphoretic. Introduction Overview login to view 6 more bullets Epidemiology Demographics login to view 2 more bullets Risk factors login to view 6 more bullets ETIOLOGY Pathophysiology login to view 1 more bullet Associated conditions login to view 1 more bullet Presentation History login to view 1 more bullet Physical exam login to view 18 more bullets Studies Labs login to view 12 more bullets Differential Serotonin syndrome login to view 5 more bullets Malignant hyperthermia login to view 4 more bullets Treatment Prevention login to view 2 more bullets Lifestyle login to view 5 more bullets Pharmacologic login to view 18 more bullets Complications Seizure Cardiac dysrhythmia Myocardial infarction Respiratory failure Hepatic failure Acute renal failure Deep venous thrombosis Disseminated intravascular coagulation Prognosis Natural history of disease login to view 1 more bullet Survival with treatment login to view 1 more bullet