Updated: 6/2/2016

Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

Topic
Review Topic
0
0
Snapshot
  • A 69-year-old male presents to clinic for follow up of his diabetes and depression.  He states that behavioral therapy has not helped for his mood and that he would be interested in trying a medication.  In addition, he also complains of a painful, electrical/tingling sensation in his legs that he was hoping you could also treat.  He is very hesitant to take any medications and would prefer to take as few as possible.
Overview
  • Drugs
    • venlafaxine
    • duloxetine
  • Mechanism
    • inhibits 5-HT and NE reuptake
      • duloxetine has greater blockade on NE
  • Clinical use
    • depression
    • fibromyalgia
    • generalized anxiety disorder
      • venlafaxine
    • diabetic peripheral neuropathy
      • duloxetine
  • Toxicity
    • most common is ↑ BP, stimulant effects
      • due to ↑ in NE
    • sedation
    • nausea
 

Please rate topic.

Average 3.7 of 3 Ratings

Thank you for rating! Please vote below and help us build the most advanced adaptive learning platform in medicine

The complexity of this topic is appropriate for?
How important is this topic for board examinations?
How important is this topic for clinical practice?
Topic COMMENTS (1)
Private Note